3 Supplement Stacks That Actually Work – Backed by Science

Written by Niels Luka, Founder of NÓNE

When it comes to supplement stacks, most advice online is either overcomplicated or pure marketing fluff. Let’s cut the noise and look at three stacks that are actually backed by research — and explain why they work.

1. Focus Stack – Lion’s Mane + L-Theanine

• Why it works: Lion’s Mane stimulates Nerve Growth Factor (NGF), supporting long-term brain health and sharper focus. L-Theanine promotes calm alertness, smoothing out distractions without making you sleepy.
  
  
• Best time to take: Morning or early afternoon.
  
  
• Study: Mori et al., 2009 (Lion’s Mane) | Kimura et al., 2007 (L-Theanine)
  
  

2. Performance Stack – Cordyceps + Shilajit

• Why it works: Cordyceps improves oxygen uptake and endurance. Shilajit supports ATP production, helping muscles recover faster and work harder for longer.
  
  
• Best time to take: 30–60 minutes before training.
  
  
• Study: Chen et al., 2010 (Cordyceps) | Pandit et al., 2016 (Shilajit)
  
  

3. Recovery Stack – Reishi + Magnesium

• Why it works: Reishi helps regulate the immune system and reduce inflammation. Magnesium supports muscle relaxation, sleep quality, and nervous system balance.
  
  
• Best time to take: Evening, 1–2 hours before bed.
  
  
• Study: Wachtel-Galor et al., 2011 (Reishi) | Abbasi et al., 2012 (Magnesium)
  

Bottom line: The right stack is targeted, simple, and built around synergy — not just throwing everything together. At NÓNE, we keep stacks clean and tested, so you know exactly what you’re taking and why.