5 Science-Backed Benefits of Adaptogenic Mushrooms

Written by Niels Luka, Founder of NÓNE

Adaptogenic mushrooms have been part of traditional medicine for centuries, but today, science is catching up. While many health claims float around online, I want to focus on what’s actually been studied and proven — and skip the hype. Here are five benefits of adaptogenic mushrooms backed by real research.

1. Improved Cognitive Function

Lion’s Mane (Hericium erinaceus) has been shown to stimulate Nerve Growth Factor (NGF) — a protein essential for the growth and survival of brain cells.
Study: Mori et al., 2009 – PubMed link
Takeaway: In a 16-week human study, participants taking Lion’s Mane scored higher on cognitive tests compared to placebo.

2. Increased Physical Endurance

Cordyceps militaris and Cordyceps sinensis are often linked to better oxygen utilization.
Study: Chen et al., 2010 – PubMed link
Takeaway: Athletes supplementing with Cordyceps saw an average increase of 11% in VO₂ max (oxygen uptake), meaning they could perform longer without fatigue.

3. Reduced Inflammation

Reishi (Ganoderma lucidum) contains triterpenes and polysaccharides that help modulate immune response and reduce inflammation.
Study: Wachtel-Galor et al., 2011 – PubMed link
Takeaway: This effect may support recovery after training and help manage chronic low-grade inflammation.

4. Better Stress Management

Adaptogens help the body return to balance after stress.
Study: Panossian et al., 2010 – PubMed link
Takeaway: Certain mushroom compounds regulate cortisol levels, improving resilience to both physical and mental stress.

5. Enhanced Immune Support

Turkey Tail (Trametes versicolor) is rich in beta-glucans that stimulate immune cell activity.
Study: Kidd, 2000 – PubMed link
Takeaway: Used in conjunction with medical treatment, Turkey Tail extracts have been shown to enhance immune defense.

Bottom line: Adaptogenic mushrooms aren’t magic, but the right ones — at the right dose — can offer real, measurable benefits. At NÓNE, we stick to clean, standardized extracts with no fillers, so what’s on the label is exactly what’s in the bag.